Pair Name	Quercitrin, Insulin
Disease Info	[ICD-11: 5A80]	Polycystic ovary syndrome		Investigative
Gene Regulation	Up-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Phosphorylation	PIK3CA	hsa5290
	Up-regulation	Expression	PM20D1	hsa148811
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
In Vitro Model	3T3-L1	Healthy	Mus musculus (Mouse)	CVCL_0123
In Vivo Model	A total of 48 (specific pathogen-free) SPF female Sprague Dawley rats (aged from six weeks, body weight of 130 –150 g) were uesd in study.
Result	PM20D1 and PI3K/Akt were required for lipolysis and endocrine regulation in PCOS-IR to restore ovarian function and maintain normal endocrine metabolism. By upregulating the expression of PM20D1, quercitrin activated the PI3K/Akt signaling pathway, improved adipocyte catabolism, corrected reproductive and metabolic abnormalities, and had a therapeutic effect on PCOS-IR.